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Healthcare

Ionis Pharmaceuticals, Inc.(IONS)

Live Price

Offline

$78.34

+2.38% today

1Y Change

+91.03%

Window

Jun 26, 2025 โ†’ Jun 23, 2026

Market Cap
$12.34B
Revenue Growth
+33.9%
EPS Growth
+21.7%
Dividend Yield
0.0%

Coverage: 248 bars ยท Jun 26, 2025 โ†’ Jun 23, 2026

Research Briefing

A compact read on the setup, peer context, quarterly changes, and recent earnings reaction.

Decision context

Research Snapshot

Ionis Pharmaceuticals, Inc. (IONS) is a Healthcare stock with a market cap of $12.34B and listed on NASDAQ. The stock last traded around $78.34 and up 91.0% across the available one-year price window (Jun 26, 2025 โ†’ Jun 23, 2026). Baseline metrics include revenue growth of +33.9%, EPS growth of +21.7%, a dividend yield of 0.0%. What stands out right now is revenue +33.9%, EPS +21.7%, free cash flow +41.4% with operating margin -33.3% and ROIC -11.1%. Valuation already assumes a fairly strong business story at price/sales 11.7. Overall, the current profile looks closer to a higher-growth but lower-margin setup than a generic broad-market placeholder. Stock Foundry combines IONS price history, valuation, growth, dividend context, earnings, analyst forecasts, news, related Healthcare peers on this page.

Benchmark Edge

IONS vs SPY, QQQ, and Sector ETFs

Normalized return, excess return, max drawdown, and calendar-year wins against the benchmarks investors actually use.

Shared 1Y chart + MAX history table

IONS

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Normalized return

SPY

--

S&P 500

Excess Return

--

Relative to SPY

IONS Max Drawdown

-19.45%

Trailing 1Y

SPY Max Drawdown

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Trailing 1Y

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Calendar-Year Returns

Uses the longest available daily history for IONS and SPY.

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Financial profile

Ionis Pharmaceuticals, Inc. (IONS)

Profitability, balance sheet stamina, and cash efficiency drawn from the latest filings.

FY Revenue

$810.5M

+38.0% YoY

FY Net Income

-$28.6M

+89.4% YoY

Free Cash Flow

$12.9M

+104.4% YoY

Revenue Growth

+33.9%

EPS Growth

+21.7%

Gross Margin

98.3%

Net Margin

-30.9%

Income statement

USD

Annual
Metric20252024202320222021
Revenue944M705M788M587M810M
Gross Profit928M694M779M573M800M
Operating Income-382M-475M-354M-410M-30M
EBITDA-287M-354M-236M-228M-5M
Net Income-381M-454M-366M-270M-29M
EPS (Diluted)โ€”โ€”โ€”โ€”โ€”

Balance sheet

USD

Point-in-time
Metric20252024202320222021
Cash & Equivalents372M242M399M276M869M
Total Assets3.5B3.0B3.0B2.5B2.6B
Total Liabilities3.0B2.4B2.6B2.0B1.8B
Shareholder Equity489M588M387M573M772M
Total Debt2.6B1.4B1.5B1.4B1.3B
Net Debt2.2B1.2B1.1B1.1B382M

Cash flow positioning

Latest Full Year

Operating Cash Flow

31M

+111.2% YoY

Capital Expenditures

18M

+10.9% YoY

Free Cash Flow

13M

+104.4% YoY

Key ratios

  • Gross Margin

    98.3%

  • Operating Margin

    -33.3%

  • Net Margin

    -30.9%

  • ROE

    -58.6%

  • Debt / Equity

    4.56x

Next Step

Turn financials into a decision

Use the numbers to decide whether this is a growth candidate, a quality compounder, or just an interesting outlier.